Pharmaceutical testing on epigenetic effects of drugs is very limited. The use of vertebrates as preclinical research models is constrained by their long mating and generational times, leading to very low numbers of progeny to test and assess. In contrast, invertebrates such as insects are ethically acceptable and convenient as a laboratory model because they breed rapidly, and produce plenty of offspring under the right circumstances. We used the red flour beetle, Tribolium castaneum, as a model to screen the effect of drugs on behavioral traits. We tested beetle growth in diets supplemented with the experimental drug curcumin at different concentrations. Curcumin is found in turmeric and helps reduce inflammation. It may help with arthritis- like pain and inflammation. Curcumin blocks the growth of certain kinds of tumors as well. The aim of this study is to examine effects on behavior, fecundity, viability and survival from exposure to this drug. We hypothesize that this chemical enhances survival of eggs and has transgenerational effects on survival among the progeny. Results will be discussed in the context of understanding transgenerational effects of commonly used drugs.
