Organochlorides are a component of pesticides. Previous studies have shown that individuals with >100ng/mL of 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p-DDE) in their blood exhibited altered methylation of the genes DIO3, TERT, and HCK; any of which could have implications in cancer progression. The goal of this study is to determine if altered methylation and expression of these genes is associated with stomach cancer. To answer this question, microarray data from the Cancer Genome Atlas was examined to determine if patient matched samples of normal and cancerous tissue displayed differences in the methylation and/or gene expression of DIO3, TERT, and/or HCK. Results from this analysis showed that DIO3 was differentially methylated (p=.003, difference in methylation =0.17).
