A Role for Circadian Rhythms in Human Chlamydial Pathogenesis

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Abstract Summary

It is known that Chlamydia pathogenesis causes complications such as pelvic inflammatory disease and tubal factor infertility. In this study, we will determine the role of circadian rhythms on the outcome of Chlamydia infection. We hypothesize that the time of day of infection is important in determining the progression of chlamydial pathogenesis. Mice were infected intravaginally with Lymphogranuloma venereum (LGV) at 10:00am (morning infected) and 10:00pm (evening infected). Vaginal swabs were taken every three days for 27 day, while blood samples and vaginal washes were collected once a week. This process was repeated for a second infection. Following the second infection, half of the mice were sacrificed, and the reproductive tract was removed for pathology.

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